NGS (Next Generation Sequencing) is a technology that breaks the genome into fragments, where the sequence of individual fragments are combined to analyze the whole genome.
The advancement in NGS technology and reduction of price led to an increased use of NGS in the fields of research and diagnostic.
The shift from sequencing individual genes to the entire genomes led the incorporation of Bioinformatics as a tool to analyze large amount of data obtained.
Q-Bomb utilizes blocking oligonucleotide, which inhibits amplification of normal DNA strands, to increase the detection rate of minute amount of DNA strands with mutations.
Q-Bomb supplements molecular barcoding, allowing it to exactly measure DNA strands with mutations.
CASAL utilize two single nucleotide polymorphisms (SNP) located nearby each other to reduce errors fromNGS sequencing and increase accuracy of the results.
CASAL is expected to be effective for prognosis of organ transplant rejections and noninvasive prenatal test (NIPT)